Ex-con Paul Little has just walked out on the only woman who has ever loved him to return to a life of crime. But when Paul gets involved with a petty thug who is later murdered, he finds himself pinned between the volatile gangster accused of the crime and the straight-laced detective who put Paul away years ago. Realizing the city may be the death of him, Paul looks to escape the circumstances that threaten to imprison him once again. The Science of Paul is a tale of redemption and self-exploration, as one man navigates the precariousness of the streets and the inner workings of his mind.